NS1′ Colocalizes with NS1 and Can Substitute for NS1 in West Nile Virus Replication
نویسندگان
چکیده
منابع مشابه
Avian influenza virus NS1
Avian influenza viruses (AIV) of H5N1 and H9N2 subtypes have zoonotic and pandemic potential. 377 out of 633 human infections with H5N1 virus were fatal and human infections by H9N2 virus were infrequently reported to the World Health Organization. Some H9N2 viruses either possessed genes similar to the H5N1 virus or were claimed to donate gene segments to H5N1 virus. Both features were reporte...
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West Nile virus (WNV) replicates in a wide variety of avian species, which serve as reservoir and amplification hosts. WNV strains isolated in North America, such as the prototype strain NY99, elicit a highly pathogenic response in certain avian species, notably American crows (AMCRs; Corvus brachyrhynchos). In contrast, a closely related strain, KN3829, isolated in Kenya, exhibits a low viremi...
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The West Nile virus (WNV) nonstructural protein NS1 is a protein of unknown function that is found within, associated with, and secreted from infected cells. We systematically investigated the kinetics of NS1 secretion in vitro and in vivo to determine the potential use of this protein as a diagnostic marker and to analyze NS1 secretion in relation to the infection cycle. A sensitive antigen ca...
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The complement system, by virtue of its dual effector and priming functions, is a major host defense against pathogens. Flavivirus nonstructural protein (NS)-1 has been speculated to have immune evasion activity, because it is a secreted glycoprotein, binds back to cell surfaces, and accumulates to high levels in the serum of infected patients. Herein, we demonstrate an immunomodulatory functio...
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The availability of an influenza virus NS1 gene knockout virus (delNS1 virus) allowed us to establish the significance of the biological relationship between the influenza virus NS1 protein and double-stranded-RNA-activated protein kinase (PKR) in the life cycle and pathogenicity of influenza virus. Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherw...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2013
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.01101-13